My broad educational and professional experience gave rise to what I believe is a unique knowledge covering,

molecular biology, genomics and drug development. All this is combined in my non-conventional thinking,

an inventive ability (proven by many patents covering some of my ideas and inventions), and a highly critical

approach in all fields.

Molecular Biology: I am a highly skilled molecular biologist, covering a very broad range of technologies, and

though I have shifted in the last 7 years into managerial and planning positions, I still have a detailed knowledge in

every aspect of the technologies from every ingredient of a reaction solution to deep understanding of the principles

behind each technology. My knowledge covers all cloning technologies, plasmid construction, analysis of gene

expression, and technologies for expressing genes both in cultured cells and in living animals. I am an expert in the

field of transgenic and knockout mice and produced hundreds of transgenic mouse lines and several knockout mice.

Many of my inventions are in the field of molecular biology and include new cloning technologies, design,

construction, and expression validation of highly efficient expression vectors both for expression in cultured cells and

in transgenic mice.

Genomics: during my professional years I was highly involved in the emerging genomics technologies. In quark

Biotech we were among the first companies to introduce the DNA microarray technology shortly after the technology

emerged (1996). I am an expert in DNA microarray technologies and have various inventions in the field. I was

instrumental in the development of functional profiling technologies and have several publications and inventions

relevant to this important field. During this time I have discovered, characterized, and patented (together with others)

several genes, relevant to a variety of diseases.

Bioinformatics: Although I am not a computer science expert I have a broad knowledge in this field that, to my

opinion, is inseparable from genomics technologies. I have followed closely the developments in this field and have the

knowledge of its powers and usefulness as well as its limitations.

Drug development: As the chief scientist of Quark Biotech I was exposed to many aspects of drug development. My

knowledge includes most types of drugs, namely, small chemicals, recombinant therapeutic proteins and peptides,

antibodies, nucleic acid based drugs, and gene therapy. I have followed the process of drug development, from

R&D into preclinical studies and clinical stages, and know most of its basics. In my last position in Rosetta

Genomics I was exposed more intensely to the field of nucleic acid based drugs and gene therapy and have a good

understanding of current developments around the world and its clinical and commercial potential. I was also exposed

to the filed of diagnostics and have knowledge of its basics.

Professional Education and Experience

2005 - today Independent consultant: Dr. Paz Einat Consulting and Inventions.

2004 - 2005 Vice President for Molecular Biology, Rosetta Genomics, Inc.

1994 - 1997 Research Scientist, QBI Enterprises LTD (Quark Biotech).

1997 – 2004 Chief Scientist, QBI Enterprises LTD (Quark Biotech).

1989 - 1994 Postdoctoral Fellow at the Department of Biology, Yale University, with Prof. Frank H. Ruddle.

Study subject: analysis of the role of homeobox genes in mouse development. Used antisense, ribozyme,

and single chain antibody (phage display) approaches to study gene function by inhibition of gene activity.

1985 - 1989 Ph.D. (awarded May, 1990) - The Weizmann Institute of Science, Rehovot, Israel, the department of

Cell Biology, with Prof. David Yaffe Moshe Shani.
Thesis subject: Studies on the regulation of expression of muscle specific genes in transgenic mice.

1982 - 1984 M.Sc. - The Weizmann Institute of Science, Rehovot, Israel, the department of Cell Biology with

Prof. David Yaffe and Dr. Moshe Shani.
Thesis subject: Changes in the chromatin structure of muscle specific genes during myogenesis.

1978 - 1981 B.Sc. in Biology with distinction. Ben Gurion University, Beer-Sheva, Israel.